Petroleum enzyme is a kind of bio-based material with catalysis, which can significantly restore the flow capacity of formation crude oil. It is an international leading mature product developed by using modern biological engineering technologies such as genetic engineering, cell engineering, and enzyme engineering to mutate and breed new strains. It has the ability to efficiently release crude oil on the surface of solid particles. It has the characteristics of catalytic oil washing activity, changing rock wettability and reducing interfacial tension.